Nationality differences in distributions of serum lipids,lipoproteins and apolipoproteins levels in Xinjiang China
10.3760/j.issn:0366-6999.2001.11.002
- VernacularTitle:新疆哈汉两民族血脂、脂蛋白(a)载脂蛋白AI及载脂蛋白B水平的比较与相关研究
- Author:
Yangchun ZOU
1
;
Bingxian HE
;
Dayi HU
;
Xinchun YANG
;
Xinli LI
;
Xinguo ZHAO
;
Ding HUANG
;
Zhu MENG
;
Shagendeke
Author Information
1. 首都医科大学附属北京朝阳医院
- Keywords:
serum lipid pedigree;
difference;
Kazak;
Hah nationality
- From:
Chinese Medical Journal
2001;114(11):1128-1131
- CountryChina
- Language:Chinese
-
Abstract:
Objective To reveal the distribution characteristics of serum lipids,lipoproteins,and apolipoproteins levels in different nationalities.Methods Quantitative levels of those traits mentioned above were determined and body height(H),weight(W)and body mass index(BMI=W/H2)were assessed in 773 Kazaks(men 360 and women 413)and 911 Han nationality(men 466 and women 445)from the Xinjiang Autonomous Region of China.Results Kazaks men and women,respectively,had significantly higher serum levels of HDL-c and ApoA1 (all P ＜ 0.001)and significantly lower serum levels of TG(men P ＜ 0.01,women P ＜ 0.001),Lp(a)(allP＜0.005),ApoB(men P＜0.005,women P＜0.001)and ApoB/A1(men P＜0.01,women P＜0.001)than their Han nationality controls.The threshold points of ApoA1(＜ 1.2 g/L)and ApoB(＞ 1.2 g/L)are higher in Hans than in Kazaks for ApoA1(20.7 vs 9.8%)and ApoB(18.6 vs 14.3%);the serum levels of TG,HDL-c,Lp(a),ApoA1 and ApoB/A1 are all closely correlated with nationality(P ＜ 0.001,P = 0.001,and P ＜ 0.05,respectively).Conclusion The results suggest that the nationality differences exist in serum levels of lipids,lipoproteins,and apolipoproteins,and Kazaks have a superior serum lipid pedigree to Hans.This differences may come from genetic differences,which affect the serum levels of lipids,lipoproteins,and apolipoproteins by controlling lipid metabolism pattems.Future study will be needed to dissect to the role of genetic factors on serum lipids.
