Apolipoprotein E gene polymorphism and its association with human longevity in the Uygur nationality in Xinjiang

VernacularTitle:新疆维吾尔族apoE基因多态性与寿命关系的分析
Author: Xinli WANG ¹ ; GuoQong WANG ; ChenRong YANG ; Xuan LI
Author Information

1. 北京大学
Keywords: apolipoprotein E; gene; longevity; Uygur
From: Chinese Medical Journal 2001;114(8):817-820
CountryChina
Language:Chinese
Abstract: Objective　To study the relationship between apoE alleles and life-span. Methods　Apolipoprotein E genotypes were determined in 164 unrelated Uygurs including 35 persons aged 90 years or older, 71 men aged 20-35 and 54 men with myocardial infarction by using polymerase chain reaction-restriction fragment length polymorphism. Apolipoprotein E gene polymorphism was analyzed among three groups. Results　There was statistically significant difference in the ε4 allele frequencies among three groups. The ε4 allele frequency in olds was the lowest (0.057), while in patients suffering from myocardial infarction (MI) was the highest (0.213). In MI patients the average age of first attack in ε4 allele carriers was significantly younger than that of non-carries, 51.3 and 58.3 years, respectively (P<0.05). Conclusion　ApoE genotype may have some impact on human longevity.