Intrathecal injection with methotrexate plus dexamethasone in the treatment of central nervous system involvement in systemic lupus erythematosus
10.3760/j.issn:0366-6999.2001.07.023
- VernacularTitle:狼疮中枢受累治疗新方法-鞘内联合注射甲氨喋呤加地塞米松
- Author:
Yi DONG
1
;
Xuan ZHANG
;
Fulin TANG
;
Xinping TIAN
;
Yan ZHAO
;
Fengchun ZHANG
Author Information
1. Peking Union Medical College Hospital
- Keywords:
lupus erythematosus,systemic;
central nervous system;
intrathecal injection
- From:
Chinese Medical Journal
2001;114(7):764-766
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Objective To investigate the effect of intrathecal injection (IT) with methotrexate (MTX) plus dexamethasone (DXM) in treating central nervous system involvement in systemic lupus erythematosus (CNS lupus). Methods Twenty-four CNS lupus patients that were refractory to conventional steroid therapy were selected for IT with MTX 10-20?mg plus DXM 10-20?mg. The effects and side effects of IT were closely observed. Results The symptoms and signs of 22/24 (91.7%) CNS lupus patients receiving IT improved considerably. Cerebrospinal fluid pressure,protein and WBC levels declined from 201.5±155.4?mm?H2O, 145.2±87.6?mg/dl and 25.1±14.3/mm3 to 128.7±108.1?mm?H2O, 60.8±38.3?mg/dl and 6.8±2.1/mm3 respectively. Transient side effects were observed in 4 patients: 1 with itching sensation of lower limbs, 2 with headache and 1 with incontinence.Conclusion IT with MTX plus DXM is a promising method for treating CNS lupus and deserves further investigation.
