Relationship between age and effect of early and long-term captopril treatment in patients with acute myocardial infarction
10.3760/j.issn:0366-6999.2001.07.007
- VernacularTitle:卡托普利治疗急性心肌梗塞早期和长期作用与年龄关系
- Author:
Xu CAI
1
;
Weifeng SHEN
;
Lansheng GONG
Author Information
1. Ruijin Hospital Shanghai Second Medical University
- Keywords:
myocardial infarction;
angiotensin-converting enzyme inhibitor;
age
- From:
Chinese Medical Journal
2001;114(7):698-702
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Objective To analyse the relationship between age and treatment with captopril after acute myocardial infarction (AMI).Methods In a randomized trial, 822 patients with a first AMI received conventional medical treatment, including intravenous thrombolytic therapy and oral aspirin or metoprolol, and then were randomly allocated to captopril [dosage from the first 6.25?mg to 25?mg/t.i.d, 209 younger patients (≤64 years), 269 elderly patients (65-75 years)] or conventional treatment only (131 younger patients, 213 elderly). Survival in the four groups was calculated with the Kaplan-Meier method. Multivariate analysis was performed to understand the degree that multi-variables (including age) affect survival in patients taking captopril in the hospital or during long term follow-up.Results The survival of patients who took captopril correlated significantly with age (P<0.001). The survival of the elderly patients on captopril treatment did increase (P<0.0001), but not of the younger ones (P>0.05) during hospitalization. During follow-up, the survival of patients who took captopril correlated insignificantly with age (P>0.05), but both the elderly and the younger patients have good survival rates (all P<0.01) and lower cardiac events (all P<0.01) when they took captopril.Conclusions Captopril exerts a weak effect on the younger patients but a beneficial effect on the elderly patients during hospitalization after AMI. However, there is no difference between the younger and the elderly in the prognosis, both having good survival and lower cardiac events when they take captopril long term during follow-up.
