Efficacy of dihydroartemisinin-mefloquine on acute uncomplicated falciparum malaria
10.3760/j.issn:0366-6999.2001.06.011
- VernacularTitle:双氢青蒿素与甲氟喹联用治疗恶性疟疾的疗效观察
- Author:
Wenqi WANG
1
;
Wei YANG
;
ST MICHA
Author Information
1. Dongguan People's Hospital
- Keywords:
malaria;
Plasmodium falciparum;
dihydroartemisinin;
mefloquine
- From:
Chinese Medical Journal
2001;114(6):612-617
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of dihydroartemisinin—mefloquine on acute uncomplicated falciparum malaria. Methods Fifty-four patients with symptomatic falciparum malaria were allocated to receive oral dihydroartemisinin at a single dose of 120?mg on day 1, followed by mefloquine, 750?mg and 500?mg on days 2 and 3, respectively. Follow-up was performed on days 1,2,3,4,7,14,21, and 28. Results All patients had a rapid initial response to treatment. The parasite clearance time (PCT) after treatment was 30.7±3.6 hours. The fever subsidence time (FST) after treatment was 21.2±2.8 hours. Two patients had a recrudescence 21 and 25 days respectively after the disappearance of parasitemia, hence the recrudescence rate was 3.7% and the cure rate was 96.3%. No serious adverse effects were observed, only mild and transient nausea, vomiting and loss of appetite. Conclusion A combination of dihydroartemisinin and mefloquine is effective in the treatment of acute uncomplicated falciparum malaria.
