Increased activity of protein kinase C in alveolar macrophages in idiopathic pulmonary fibrosis
10.3760/j.issn:0366-6999.2001.03.021
- VernacularTitle:肺间质病病人肺泡巨噬细胞蛋白激酶C活性增高
- Author:
Lingzhi LIU
1
;
Zhenhua LI
;
Runjiang YU
Author Information
1. 中国医科大学
- Keywords:
protein kinase C idiopathic pulmonary fibrosis alveolar macrophages
- From:
Chinese Medical Journal
2001;114(3):321-323
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes on protein kinase C (PKC) activity of alveolar macrophages (AMs) in patients with idiopathic pulmonary fibrosis (IPF). Methods The PKC activity of AM in 9 healthy volunteers and 15 patients with IPF was investigated by measuring the radioactivity. Results The total, cytosolic and membrane PKC activity of AM in bronchoalveolar lavage fluid (BALF) from patients with IPF were higher than those from control group (P<0.01, P<0.05 and P<0.05, respectively). The total and the membrane-associated PKC activity had a positive correlation with the number of cells in BALF (r=0.8135, P<0.01 and r=0.5917, P<0.05), respectively. Conclusion As a bypass of transmembrane signal transduction, PKC was suggested to be involved in the origination and development of IPF.
