Retinoic acid regulated insulin-like growth factor gene expression in cord blood lymphocytes
10.3760/j.issn:0366-6999.2001.02.014
- VernacularTitle:视黄酸调节胰岛素样生长因子基因在脐血淋巴细胞的表达
- Author:
Yi YANG
1
;
Weiping WANG
;
Yixin SU
Author Information
1. Pediatrics Hospital Shanghai Medical University
- Keywords:
retinoic acid;
insulin like growth factor;
cord blood lymphocyte
- From:
Chinese Medical Journal
2001;114(2):170-172
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the immune promotion mechanism of retinoic acid (RA). Methods Reverse Transcription-Polymerase chain reaction (RT-PCR) was used to detect the gene expression of insulin like growth factor Ⅰ (IGF-Ⅰ) and IGF receptors (IGF-IR and IGF-IIR) in vitro, and their regulation by RA in human cord blood lymphocyte (CBL). Results Significant upregulation of IGF-I, IGF-IR and IGF-IIR mRNA was found at 6-24 hours in CBL incubated with physiologic concentrations of RA as compared to those without RA. Conclusion The enhancement of IGF expression may be an important pathway for vitamin A to promote immune cellular functions.
