Expression of β-catenin in renal cell carcinoma
10.3760/j.issn:0366-6999.2001.02.010
- VernacularTitle:β-环连蛋白及其mRNA在肾癌中的表达
- Author:
Tong ZANG
1
;
Liyan ZHUANG
;
Zhiwen ZHANG
;
Dianqi XIN
;
Yinglu GUO
Author Information
1. 北京医科大学附属第一医院
- Keywords:
kidney neoplasm;
carcinoma;
β-catenin
- From:
Chinese Medical Journal
2001;114(2):152-154
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of β-catenin and its mRNA in renal cell carcinoma. Methods Twenty-six cases with renal cell carcinoma (RCC) were studied by immunohistochemistry, Western blot and RT-PCR. Results We found the expression of β-catenis is higher in cancer tissues than in normal kidney tissues and the level of β-catenin is associated with the tumor stage. Its expression in tumor of pT3 and pT4 is obviously higher than pT1 and pT2 (P<0.01). That is to say, there was an overexpression of β-catenin protein in RCC and its level was related to the tumor stage, but the expression of β-catenin mRNA had no difference between tumor tissue and normal tissue. Conclusion β-catenin may be related to the occurrence and progress of RCC.
