Efficacy of Carboxymethylcellulose and Hyaluronate in Dry Eye Disease: A Systematic Review and Meta-Analysis.
- Author:
Jae Kyeong SONG
1
;
Kiheon LEE
;
Hwa Yeon PARK
;
Joon Young HYON
;
Seung Won OH
;
Woo Kyung BAE
;
Jong Soo HAN
;
Se Young JUNG
;
Yoo Jin UM
;
Ga Hye LEE
;
Ji Hye YANG
Author Information
- Publication Type:Meta-Analysis ; Randomized Controlled Trial ; Original Article
- Keywords: Xerophthalmia; Carboxymethylcellulose Sodium; Hyaluronate; Fluorescein Tear Breakup Time
- MeSH: Bias (Epidemiology); Carboxymethylcellulose Sodium*; Eye Diseases*; Humans; Lubricant Eye Drops; Tears; Xerophthalmia
- From:Korean Journal of Family Medicine 2017;38(1):2-7
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: The efficacy of two artificial tears, carboxymethylcellulose (CMC) and hyaluronate (HA), was compared in the treatment of patients with dry eye disease. METHODS: We conducted a systematic review and meta-analysis on randomized controlled trials in the PubMed, Embase, Cochrane Library, and ClinicalTrials.gov databases. The efficacy was compared in terms of the mean change from baseline in tear break-up time. The meta-analysis was conducted using both random and fixed effect models. The quality of the selected studies was assessed for risk of bias. RESULTS: Five studies were included involving 251 participants. Random effect model meta-analysis showed no significant difference between CMC and HA in treating dry eye disease (pooled standardized mean difference [SMD]=-0.452; 95% confidence interval [CI], -0.911 to 0.007; P=0.053). In contrast, fixed effect model meta-analysis revealed significant improvements in the CMC group when compared to the HA group (pooled SMD=-0.334; 95% CI, -0.588 to -0.081; P=0.010). CONCLUSION: The efficacy of CMC appeared to be better than that of HA in treating dry eye disease, although meta-analysis results were not statistically significant. Further research is needed to better elucidate the difference in efficacy between CMC and HA in treating dry eye disease.
