192Ir endovascular irradiation prevents restenosis after balloon angioplasty in rabbit

VernacularTitle:192Ir 血管内照射防止兔球囊血管成形术后再狭窄
Author: Ming CHEN ¹ ; Yong HUO ; Zhaoping LIU ; Risheng WANG ; Guoying ZHU
Author Information

1. 北京大学医学部附属第一医院(北大医院)
Keywords: angioplasty; restenosis; endovascular irradiation
From: Chinese Medical Journal 2001;114(1):62-63
CountryChina
Language:Chinese
Abstract: Objective　To examine the effect of endovascular irradiation on restenosis after balloon angioplasty in rabbit. Methods　After the establishment of rabbit iliac atherosclerosis model, balloon angioplasty was performed at the lesion segment of the iliac artery. Rabbits were randomly divided into three groups: control group, 10 Gy irradiated group and 18 Gy irradiated group. Endovascular irradiation was performed for irradiated groups at the dilated sites by introducing the 192Ir radioactive guidewire through a catheter. After four weeks, the animals were killed and the target segments were cut down. Histopathologic and morphometric analyses were carried out. Results　The mean final lumen area in the 18 Gy group was larger than that in the control or 10 Gy group (P<0.05). The intimal area in the 18 Gy group was smaller (P<0.05). Conclusions　192Ir endovascular irradiation may prevent restenosis after balloon angioplasty. The effect is related to the delivered dose. The mechanism is involved in inhibition of neointimal proliferation.