Clinicopathologic study of mucosa-associated lymphoid tissue lymphoma of the salivary gland
10.3760/j.issn:0366-6999.2001.01.009
- VernacularTitle:涎腺淋巴瘤临床与病理研究
- Author:
Qunli SHI
1
;
Taihe ZHANG
;
Qiaozhen XUE
;
Kewu FAN
;
Guiqin SUN
;
Xiaojuan YAN
;
Boquan SHOU
;
Bin YU
Author Information
1. Nanjing General Hospital of PLA
- Keywords:
salivary gland;
mucosa-associated lymphoid tissue;
lymphoma;
immunohistochemistry;
electron microscope
- From:
Chinese Medical Journal
2001;114(1):44-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the histopathologic features and pathogenesis of mucosa-associated lymphoid tissue lymphoma (MALT-oma) of salivary glands. Methods Clinical data, paraffin-embedded sections, immunohistochemical slides (SP method) and electron microscopic features of surgical specimens of 32 cases of salivary gland MALT-oma were studied. Results The patients were 27 males and 5 females, with a mean age of 54.76 years. The lesions were located in the parotid area in 17 cases, and in the submandibular gland in the remaining 15 cases. Much of the MALT-oma was replaced by infiltration of a great amount of centrocyte-like cells (CCL) as background and occasional large cells (centroblast- or immunoblast-like). In MALT-omas “lymphoepithelial lesions" were present. Immunohistochemically, CD20 expression was found to be positive and CD45RO expression was negative in all MALT-omas. Conclusion Most of the MALT-omas are low grade malignant tumors and have a “homing back" phenomenon. The cases were managed by surgery and chemotherapy. In a few MALT- omas which turned into high grade malignant tumors, the prognosis was poor. Acquired MALT may develop as a reaction to autoimmune disease and infection. Hyper-immune reaction and MALT hyperplasia under stimulation may result in myoepithelial sialadenitis and lead to MALT-oma of the salivary gland.
