Sma Ⅰ, Hha Ⅰ, Msp Ⅰ and Rsa Ⅰ restriction fragment length polymorphisms in the von Willebrand factor gene of Chinese population
- Author:
Zhenyu LI
1
;
Yong WANG
;
Hong TAI
;
Haiying WAN
;
Jianxin SONG
;
Yingchun WANG
;
Changgeng RUAN
Author Information
1. 苏州医学院附属第一医院
- From:
Chinese Medical Journal
1998;111(8):686-689
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study Sma Ⅰ, Hha Ⅰ, Msp Ⅰ and Rsa Ⅰ restriction fragment length polymorphisms in vWF gene of Chinese population. Methods The vWF gene from 52 unrelated individuals of Han Nationality, 44 of Yi tribe, 42 of Dai tribe was analyzed by polymerase chain reaction and digestion of the endonucleases of Sma Ⅰ, Hha Ⅰ, Msp Ⅰ and Rsa Ⅰ.Conclusions The allele frequencies and theoretical rates of these polymorphisms in vWF gene are different between Chinese populations and Caucasians. They should be useful for the carrier detection and prenatal diagnosis in vWD families of Chinese.
