Growth regulation of ovarian cancer cell line HO-8910 by transforming growth factor β1 in vitro
- Author:
Xufeng CHEN
1
;
Shu ZHENG
;
Yongliang GAO
;
Huifang DAI
;
Hanzhou MOU
;
Hua YANG
Author Information
1. 浙江医科大学
- From:
Chinese Medical Journal
1998;(6):546-550
- CountryChina
- Language:Chinese
-
Abstract:
Objective To further understand the role of growth regulation of human ovarian cancer cells by transforming growth factor (TGF) β1.Methods The cell proliferation, cAMP synthesis, gene expression, and induction of programmed cell death (PCD) in human epithelial ovarian cancer cell line HO-8910 cells exposed to TGFβ1 in vitro were studied.Results TGFβ1 inhibited cell growth and DNA synthesis, and induced G0/G1 arrest in cell cycle. It could also trigger PCD in cells. This induction of PCD may occur within G0/G1 phase. Meanwhile, the assay also showed that TGFβ1 could inhibit the mRNA expression of c-myc, EGFR and TGFβ1 genes in cells.Conclusions TGFβ1 can not only act as an autocrine to inhibit cell proliferation, but also trigger PCD in HO-8910 cells. These functions may be fulfilled through some specific signal transduction pathways.
