Effects of β-amyloid peptide on transient outward potassium current of acutely dissociated hippocampal neurons in CA1 sector in rats
- Author:
Changqing XU
1
;
Caiyun QIAN
;
Zongming ZHANG
;
Caihong WU
;
Paiai ZHOU
;
Xiuling LIANG
Author Information
1. 中山大学附属第一医院
- From:
Chinese Medical Journal
1998;(6):492-495
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of β-amyloid peptide (β-AP) in Alzheimer's disease at ionic channel level.Methods Hippocampal CA1 neurons of 7-21 days' rats were acutely dissociated and the effects of β-AP on transient outward potassium current were observed by a whole-cell recording patch clamp technique.Results β-AP can significantly block transient potassium current in dose-dependent, time-dependent and partly voltage-dependent manners.Conclusion β-AP may decrease the membrane conductance of K+ channels in hippocampal neurons, playing an important role in the pathophysiological mechanism of Alzheimer's disease.
