Contrast-Induced Nephropathy in Patients Undergoing Intravenous Contrast-Enhanced Computed Tomography in Korea: A Multi-Institutional Study in 101487 Patients.
10.3348/kjr.2014.15.4.456
- Author:
Joongyub LEE
1
;
Jeong Yeon CHO
;
Hak Jong LEE
;
Yong Yeon JEONG
;
Chan Kyo KIM
;
Byung Kwan PARK
;
Deuk Jae SUNG
;
Byung Chul KANG
;
Sung Il JUNG
;
Eun Ju LEE
;
Boem Ha YI
;
Seong Jin PARK
;
Jong Chul KIM
;
Dae Chul JUNG
;
Chang Kyu SUNG
;
Yongsoo KIM
;
Youngrae LEE
;
Sun Ho KIM
;
Seong Kuk YOON
;
Byung Joo PARK
;
Seung Hyup KIM
Author Information
1. Medical Research Collaborating Center, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 110-799, Korea.
- Publication Type:Original Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
- Keywords:
Contrast-induced nephropathy;
Contrast-enhanced computed tomography;
Prevalence;
Risk factor
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Comorbidity;
Contrast Media/*adverse effects;
Female;
Glomerular Filtration Rate;
Humans;
Incidence;
Kidney Diseases/*chemically induced/epidemiology/*radiography;
Male;
Middle Aged;
Prevalence;
Republic of Korea/epidemiology;
Risk Factors;
Tomography, X-Ray Computed/*methods
- From:Korean Journal of Radiology
2014;15(4):456-463
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To evaluate the prevalence of known risk factors for contrast-induced nephropathy (CIN) and their association with the actual occurrence of CIN in patients undergoing intravenous contrast-enhanced computed tomography (CECT) in Korea. MATERIALS AND METHODS: Patients who underwent CECT in 2008 were identified in the electronic medical records of 16 tertiary hospitals of Korea. Data on demographics, comorbidities, prescriptions and laboratory test results of patients were collected following a standard data extraction protocol. The baseline renal function was assessed using the estimated glomerular filtration rate (eGFR). We identified the prevalence of risk factors along the eGFR strata and evaluated their influence on the incidence of CIN, defined as a 0.5 mg/dL or 25% increase in serum creatinine after CECT. RESULTS: Of 432425 CECT examinations in 272136 patients, 140838 examinations in 101487 patients met the eligibility criteria for analysis. The mean age of the participants was 57.9 +/- 15.5 years; 25.1% of the patients were older than 70 years. The prevalence of diabetes mellitus was 11.9%, of hypertension 13.7%, of gout 0.55% and of heart failure was 1.7%. Preventive measures were used in 40238 CECT examinations (28.6%). The prevalence of risk factors and use of preventive measures increased as the renal function became worse. A CIN was occurred after 3103 (2.2%) CECT examinations, revealing a significant association with decreased eGFR, diabetes mellitus, and congestive heart failure after adjustment. CONCLUSION: Risk factors for CIN are prevalent among the patients undergoing CECT. Preventive measures were seemingly underutilized and a system is needed to improve preventive care.
