Mechanisms and perspectives of B vitamins associated one carbon metabolism on colorectal cancer risk
10.3760/cma.j.cn112150-20240517-00400
- VernacularTitle:B族维生素相关一碳代谢与结直肠癌发生发展关系的研究
- Author:
Yanhui MA
1
;
Lisong SHEN
;
Yingxia ZHENG
Author Information
1. 上海交通大学医学院附属新华医院检验科，上海 200092
- Keywords:
Colorectal cancer;
One-carbon metabolism;
Folate;
Vitamin B2;
Vitamin B6;
Vitamin B12
- From:
Chinese Journal of Preventive Medicine
2024;58(11):1739-1751
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer (CRC) represents a significant global health challenge as a common malignancy of the digestive tract. The involvement of B vitamins—specifically folic acid (B9), riboflavin (B2), pyridoxine (B6), and cobalamin (B12)—is crucial in metabolic processes by mediating the transfer of one-carbon (1C) units, which plays a fundamental role in cellular functions and tumor growth. 1C metabolism is involved in synthesis of proteins, lipids, nucleic acids, and other cofactors. 1C metabolism, intertwined with the metabolism of other nutrients, forms complex pathways where B vitamins act as precursors or coenzymes, influencing the production of various intermediates. These vitamins, as essential nutrients, are implicated to varying the pathogenesis and progression of colorectal cancer such as epigenetics. Furthermore, 1C metabolism affects tumor cell fate through multiple aspects including nucleotide synthesis, redox homeostasis, and the interaction with gut microbiota. Given these roles, understanding and monitoring B vitamin levels and their metabolic pathways are essential for colorectal cancer prevention and management. This approach not only helps in reducing tumor-related mortality but also opens new avenues for research into CRC mechanisms and potential therapeutic strategies.
