Advances in the application of liquid chromatography tandem mass spectrometry for therapeutic drug monitoring
10.3760/cma.j.cn112150-20240419-00328
- VernacularTitle:液相色谱串联质谱技术在治疗药物监测中的应用进展
- Author:
Jiexin LIU
1
;
Wei GUO
Author Information
1. 复旦大学附属中山医院检验科，上海 200032
- Keywords:
Drug monitoring;
Chromatography, Liquid;
Mass spectrometry
- From:
Chinese Journal of Preventive Medicine
2024;58(10):1604-1609
- CountryChina
- Language:Chinese
-
Abstract:
Therapeutic drug monitoring is a good interpretation of personalized medicine, which helps to improve the safety and effectiveness of patient medication. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has gradually been widely accepted by clinical laboratories due to its characteristics of specificity, sensitivity, and flexibility in method development. This article introduces the importance and analytical techniques for therapeutic drug monitoring, describes the application and development of liquid chromatography tandem mass spectrometry for therapeutic drug monitoring, new advances in the detection of different drug types and sample types, and challenges in automation, convenience, and standardization.
