Research progress of lipid-derived parameters in atherosclerotic cardiovascular disease
10.3760/cma.j.cn112150-20240304-00183
- VernacularTitle:血脂衍生参数在动脉粥样硬化性心血管疾病中的研究进展
- Author:
Sizhuang HUANG
1
;
Mengyue YU
Author Information
1. 中国医学科学院北京协和医学院 国家心血管病中心 阜外医院特需医疗中心，北京 100037
- Keywords:
Dyslipidemia;
Atherosclerotic cardiovascular disease;
Lipid-derived parameters
- From:
Chinese Journal of Preventive Medicine
2024;58(9):1438-1443
- CountryChina
- Language:Chinese
-
Abstract:
Dyslipidemia stands as an autonomous peril in the realm of atherosclerotic cardiovascular maladies. Prompt identification and timely intervention in the case of dyslipidemia hold promise for substantially curbing the onset and fatality rates associated with coronary heart disease. Traditional lipid surveillance metrics employed in clinical settings, such as low-density lipoprotein cholesterol, exhibit notable limitations. Conversely, lipid-derived parameters emerge as formidable contenders, demonstrating a capacity to amalgamate and quantify disparate risk factors and multifactorial etiologies inherent in a given disease. By encompassing a broader spectrum of information than singular indices, these parameters offer a more profound insight into disease progression by virtue of their grounding in the physiological intricacies of lipid metabolism. Drawing upon extant domestic and international guidelines and research, this discourse delineates and synthesizes four lipid-derived parameters with promising clinical applications: atherogenic index of plasma, non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio, apolipoprotein B/A1 ratio, and lipoprotein combine index, and forwards a perspective grounded in current strides in clinical research.
