Research progress on exosomes and their non-coding RNAs in the diagnosis of neurodegenerative diseases

VernacularTitle:外泌体及其非编码RNA在神经退行性疾病诊断中的研究进展
Author: Binpan WANG ¹ ; Yan PI ; Ming CHEN ; Kai CHANG
Author Information

1. 陆军军医大学第一附属医院检验科，重庆　400038
Keywords: Exosomes; Exosomal non-coding RNAs; Neurodegenerative diseases; Diagnosis
From: Chinese Journal of Preventive Medicine 2024;58(9):1415-1422
CountryChina
Language:Chinese
Abstract: Neurodegenerative diseases, originating from irreversible progressive loss of neuronal structure or function, are difficult to diagnose and treat. They vary widely in scope and have poor prevention and prognosis. Therefore, research on their early diagnosis is particularly important. Exosomes are small vesicles of cellular origin that contain various bioactive small molecules, such as proteins, RNAs, and DNAs, and play important roles in intercellular communication. Recent studies have shown that exosomes and their non-coding RNAs are key factors in the pathogenesis of various neurodegenerative diseases. Therefore, exosomes and their non-coding RNAs may provide a breakthrough for the early diagnosis of neurodegenerative diseases. This review summarizes the biology of exosomes and the current research progress of exosomes and their non-coding RNAs in diagnosing neurodegenerative diseases and further explores the challenges and prospects they face.