Association of urinary cadmium levels with peripheral leukocyte classification counts among middle-aged and older adults aged 40-89 in selected areas of China
10.3760/cma.j.cn112150-20240222-00137
- VernacularTitle:我国部分地区40~89岁中老年人尿镉水平与外周血白细胞分类计数的关联研究
- Author:
Yufei LUO
1
;
Yuan WEI
;
Xiaochen WANG
;
Yi ZHANG
;
Wenli ZHANG
;
Bing WU
;
Zhengxiong YANG
;
Xiaojie DONG
;
Ruiting HAO
;
Yifu LU
;
Xiaoshuang FU
;
Ziyue ZHU
;
Ying ZHU
;
Yuebin LYU
;
Dongqun XU
;
Xiaoming SHI
Author Information
1. 安徽医科大学公共卫生学院，合肥 230032
- Keywords:
Cadmium;
Leukocyte count;
Lymphocyte count;
Middle-aged and older adults
- From:
Chinese Journal of Preventive Medicine
2024;58(6):839-846
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of urinary cadmium levels with peripheral leukocyte classification counts among middle-aged and older adults aged 40 to 89 years in selected areas of China.Methods:The research was based on the survey of the impact of soil quality of agricultural land on human health in typical areas conducted in 2019-2020. A total of 5 600 middle-aged and older adults aged 40 to 89 years were included by using a multi-stage stratified random sampling method. Baseline characteristics of the subjects were collected and physical examinations were performed. Random midstream urine was collected to measure urinary cadmium and urinary creatinine and fasting venous blood was collected to measure the leukocyte count, neutrophil count, lymphocyte count, monocyte count and eosinophil count. The linear mixed effect model was used to analyse the association of urinary cadmium levels with leukocyte classification counts, and the dose-response relationship between them was analyzed by using the restricted cubic spline (RCS) function.Results:The age of the subjects was (63.17±12.02) years; 2 851 (50.91%) were males; and the M ( Q 1, Q 3) of urinary creatinine-corrected urinary cadmium levels was 2.69 (1.52, 4.69) μg/g·creatinine. After adjusting for confounding factors, the results of linear mixed effects model analysis showed that for each 1-unit increase in urinary creatinine-corrected urinary cadmium level, the percentage change [% (95% CI)] of leukocyte count and lymphocyte count was -1.70% (-2.61%, -0.79%) and -1.57% (-2.86%, -0.26%), respectively. RCS function showed a negative linear relationship between urinary creatinine-corrected urinary cadmium levels and leukocyte counts and lymphocyte counts, respectively (all Pnon-linear>0.05). Conclusion:Urinary cadmium levels are negatively associated with leukocyte count and lymphocyte count among middle-aged and older adults aged 40 to 89 years in selected areas of China.
