Analysis of factors associated with infection and death of carbapenem-resistant Klebsiellapneumoniae
10.3760/cma.j.cn112150-20231005-00235
- VernacularTitle:碳青霉烯耐药肺炎克雷伯菌感染和死亡的相关因素分析
- Author:
Xiao WANG
1
;
Yihai GU
;
Wei ZHANG
;
Yan JIANG
;
Minghui DENG
;
Xuan HOU
;
Mengrong ZHOU
;
Hui WANG
;
Xiaobo LI
Author Information
1. 陕西中医药大学医学技术学院，咸阳 712046
- Keywords:
Klebsiella pneumoniae;
Related factors;
Carbapenem;
Case-control studies
- From:
Chinese Journal of Preventive Medicine
2024;58(4):545-551
- CountryChina
- Language:Chinese
-
Abstract:
To analyze the factors associated with infection and death of carbapenem-resistant Klebsiella pneumoniae (CRKP) in patients. Using a case-control study method, patients with CRKP infection from January 2019 to December 2021 in the 3201 Hospital were selected as the case group, and patients with carbapenem-susceptible Klebsiella pneumoniae (CSKP) infection in the same period were selected as the control group in a ratio of 1∶1. The study subjects were followed up for 30 days. The two groups of patients were categorized into survival and death groups based on whether they died or not, respectively, and the 30-day morbidity and mortality rates of the CRKP case group and the CSKP control group were compared. The logistic regression model was used to analyze the factors associated with CRKP infection and death after CRKP infection. This study included 59 cases in the CRKP case group and 59 in the CSKP control group. The 30-day mortality rate of CRKP-infected patients and CSKP-infected patients were 30.5% (18/59) and 5.1% (3/59), with statistically significant differences ( P<0.001). Surgery within three months prior to KP infection ( OR=17.285, P=0.001), use of carbapenems within three months prior to KP infection ( OR=11.235, P=0.002), use of more than three types of antibiotics ( OR=7.993, P=0.016), albumin<30 g/L in patients prior to KP infection ( OR=10.463, P=0.002), sex ( OR=0.078, P<0.001), and diabetes ( OR=0.076, P=0.011) were associated factors of CRKP infection. Higher age-corrected Charlson Comorbidity Index scores of patients ( OR=1.522, P=0.024) and use of carbapenems by the patients with in the first three months prior to the KP infection ( OR=4.902, P=0.029) were associated factors for the deaths of patients with CRKP. In conclusion, medical personnel should be cautious in performing invasive procedures, strictly control the use of antibiotics, and provide targeted protection and treatment for high-risk patients as soon as possible.
