Associations between personal fine particulate matter and blood lipid profiles: A panel study in Chinese people aged 60-69 years
10.3760/cma.j.cn112150-20220525-00527
- VernacularTitle:大气细颗粒物短期暴露对老年人血脂代谢的影响
- Author:
Jiaonan WANG
1
;
Tiantian LI
;
Jianlong FANG
;
Song TANG
;
Yi ZHANG
;
Fuchang DENG
;
Chong SHEN
;
Wanying SHI
;
Yuanyuan LIU
;
Chen CHEN
;
Qinghua SUN
;
Yanwen WANG
;
Yanjun DU
;
Haoran DONG
;
Xiaoming SHI
Author Information
1. 南京医科大学公共卫生学院全球健康中心，南京 211166
- Keywords:
PM 2.5;
Aged;
Dyslipidemias;
Panel study
- From:
Chinese Journal of Preventive Medicine
2022;56(7):897-901
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between short-term exposures to fine particulate matter (PM 2.5) on blood lipids in the elderly. Methods:In this panel study, five repeated measurements were performed on 76 people aged 60-69 in Jinan city. Each participant had a PM 2.5 monitor for 72 hours before each health examination, including a questionnaire survey, physical examination, and biological sample collection. Serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were examined, and non-HDL-C concentrations were calculated by subtracting HDL-C from TC. The generalized linear mixed-effects model was used to quantify the association of personal PM 2.5 exposure at different lag with blood lipids and dyslipidemia. Results:The age of 70 participants was (65.0±2.8) years, of which 48.6% (34/70) were males. The BMI of participants was (25.0±2.5) kg/m 2. Their TC, TG, LDL-C, HDL-C, and non-HDL-C concentrations were (5.75±1.32), (1.55±0.53), (3.27±0.94), (1.78±0.52), and (3.97±1.06) mmol/L, respectively. Generalized linear mixed-effects model showed that after adjusting for confounding factors, at lag 72 hours, each 10 μg/m 3 increase in PM 2.5 was associated with the percentage change in TC, LDL-C, HDL-C and non-HDL-C about 1.77% (95% CI: 1.22%-2.32%), 1.90% (95% CI: 1.18%-2.63%), 1.99% (95% CI: 1.37%-2.60%) and 1.74% (95% CI: 1.11%-2.37%), and the OR values (95% CI) of hypercholesterolemia, hypertriglyceridemia and hyperbetalipoproteinemia were 1.11 (1.01-1.22), 1.33 (1.03-1.71) and 1.15 (1.01-1.31), respectively. Conclusion:There is a significant association of short-term PM 2.5 exposure with the concentration of blood lipids and the risk of dyslipidemia in the elderly.
