Association of high-density lipoprotein cholesterol with risk of cardiovascular disease mortality
10.3760/cma.j.cn112150-20201217-01458
- VernacularTitle:血清高密度脂蛋白胆固醇水平与心脑血管疾病死亡的相关性
- Author:
Junjie BAO
1
;
Tiezheng LI
;
Zongming YANG
;
Yao ZHU
;
Jieming LU
;
Peng SHEN
;
Hongbo LIN
;
Kun CHEN
;
Jianbing WANG
Author Information
1. 浙江大学公共卫生学院，杭州 310058
- Keywords:
Cholesterol, high density lipoprotein;
Cardiovascular diseases;
Risk of mortality;
Cohort study
- From:
Chinese Journal of Preventive Medicine
2021;55(12):1461-1467
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the association between high density lipoprotein cholesterol (HDL-C) and the risk of cardiovascular disease mortality.Methods:A total of 71 618 residents aged over 18 years with complete baseline data, who were filed on the health information big data platform of Yinzhou district, Ningbo city, Zhejiang Province from 2009 to 2014, were selected as the research population. The research population were divided into four groups according to the level of HDL-C: low-level group (HDL-C<1.0 mmol/L), intermediate-level group (1.0 mmol/L≤HDL-C<1.5 mmol/L), medium-high-level group (1.5 mmol/L≤HDL-C<2.0 mmol/L) and high-level group (HDL-C≥2.0 mmol/L). Cox proportional hazard model was used to calculate the risk ratio of cardiovascular diseases mortality in different groups.Results:The study population was followed up for a total of 427 989.4 person-years, follow-up time of (5.98±1.04)years. During the follow-up period, there were 799 deaths due to cardiovascular diseases. After adjusting for confounding factors, compared with the medium-high-level group as the reference group, the HR (95% CI) for cardiovascular diseases mortality was 1.43 (1.13-1.82) in the low-level group and 1.22 (1.02-1.46) in the high-level group. Conclusion:The low level of HDL-C (<1.5 mmol/L) is associated with a higher risk of cardiovascular disease deaths. The level of HDL-C can be used as a biological indicator to monitor the development of cardiovascular diseases and guide treatment.
