Antigenic evolution of influenza virus and the implications for influenza vaccine development
10.3760/cma.j.cn112150-20210802-00740
- VernacularTitle:流感病毒抗原性进化及对流感疫苗研发的启示
- Author:
Yimeng AN
1
;
Xu ZHOU
;
Youchun WANG
;
Weijin HUANG
Author Information
1. 上海生物制品研究所有限责任公司 200051
- Keywords:
Influenza, human;
Viruses;
Antigenic variation;
Vaccines
- From:
Chinese Journal of Preventive Medicine
2021;55(11):1339-1345
- CountryChina
- Language:Chinese
-
Abstract:
Influenza virus has a continuous and extensive impact on human health around the world. Its extensive animal host characteristics and highly variable characteristics lead to continuous antigen drift and change of susceptible populations, causing repeated global influenza epidemics, and also affecting the protective effect of seasonal influenza vaccine. This research in a number of subtypes of influenza a virus, for example, from the antigenic drift of antigenicity, influence of the seasonal influenza vaccine strains and popular strain compatibility, broad-spectrum flu vaccine development train of thought, etc. summarizes the progress of relevant research, to deepen the understanding of the influenza virus antigenic evolution, provide reference for flu vaccine development in the future.
