Dose-effect relationship between serum polycyclic aromatic hydrocarbon adducts and serum complements among children in a city of East China
10.3760/cma.j.cn112150-20210112-00031
- VernacularTitle:中国华东某城市儿童血清中多环芳烃加合物与血清补体的剂量-效应关系研究
- Author:
Zhenjie WANG
1
;
Yang LIN
;
Jingjing YIN
;
Liya ZHANG
;
Ting WANG
;
Yanhua WANG
;
Nan WU
;
Fanling KONG
;
Huawei DUAN
Author Information
1. 中国疾病预防控制中心职业卫生与中毒控制所，北京100050
- Keywords:
Particulate matter;
Complement C4;
Adducts;
Polycyclic aromatic hydrocarbons
- From:
Chinese Journal of Preventive Medicine
2021;55(5):653-659
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the dose-response relationship between serum polycyclic aromatic hydrocarbon adducts and serum complement C3 and C4 levels among children from a city in East China.Methods:In September 2016, two boarding schools in the air pollution exposure area and the control area (beyond the upwind of 30 km in the air pollution exposure area) in a city in East China were selected as the research site, and the eligible school-age children were recruited as the research objects. A total of 273 children were included, including 163 in the exposure group and 110 in the control group. The annual air pollutant data (PM 2.5, PM 10 and NO 2) of the two regions during the study period were collected. The exposure level of tobacco was evaluated by cotinine in urine. The levels of serum complement C3 and C4 were determined by automatic biochemical analyzer. The serum anti-7, 8, -dihydrodiol-9, 10-epoxide benzo[a]pyrene (BPDE)-albumin adduct levels were detected by ELISA. Linear regression model was used to explore the dose-response relationship between BPDE-albumin adducts and serum complement C3 and C4. Results:The age of 273 subjects was (13.67±0.37) years old, including 165 boys (60.4%). The average annual exposure levels of PM 2.5, PM 10 and NO 2 and the level of serum BPDE-albumin adducts in the exposure group were higher than those in the control group ( P<0.05). The results of linear regression model analysis showed that after adjusting age, sex, BMI z-score and urinary cotinine level, when the serum BPDE-albumin adduct level increased by 10%, the serum complement C4 level decreased by 1.2% ( P=0.017). After adjusting age, BMI z-score and urinary cotinine level, for every 10% increase in serum BPDE-albumin adduct level in boys, the serum complement C4 level decreased by 1.68% ( P=0.024). After adjusting age, sex and BMI z-score, the levels of serum complement C3 and C4 decreased by 1.31% and 3.57% respectively for every 10% increase in serum BPDE-albumin adducts among children in the urinary cotinine detection group ( P<0.05). Conclusion:There is a significant dose-response relationship between serum BPDE-albumin adducts and the complement C4 among children.
