The mechanism, prevention and diagnosis of cutaneous adverse drug reaction
10.3760/cma.j.cn112150-20210317-00265
- VernacularTitle:药疹发病机制及预防诊断相关问题
- Author:
Dandan XU
1
;
Ming GUAN
;
Xiaoqun LUO
Author Information
1. 复旦大学附属华山医院变态反应科，上海 200040
- Keywords:
Drug hypersensitivity;
Drug eruptions;
Human leukocyte antigen;
Genetic loci;
Culprit drug;
Drug provocation test;
In vivo test;
In vitro test
- From:
Chinese Journal of Preventive Medicine
2021;55(5):574-582
- CountryChina
- Language:Chinese
-
Abstract:
Adverse drug reactions are often encountered in the process of medication and are quite troublesome for clinicians. Skin is one of the most frequently affected organs by adverse drug reactions. Adverse drug reactions involving skin are called "drug-induced dermatitis" or "drug eruption". In some rare instances, drug eruption can be severe and life-threatening which is known as severe cutaneous adverse drug reaction. However, due to the mixed use of drugs, it is difficult to identify the culprit drug, which makes multiple drugs needed to be avoided. Recently, many studies have found that HLA alleles are closely related to the certain culprit drug. HLA genotyping before administration can significantly reduce the incidence of severe cutaneous adverse drug reaction related to certain drugs. Since limited HLA alleles are found, HLA genotyping can only prevent adverse drug reaction to a limited extent. At present, drug provocation tests are regarded as the "gold standard" to identify the culprit drug. However, this diagnostic program has not been widely developed because of the high risk. In addition, a variety of in vivo and in vitro diagnostic methods (including drug patch test, drug skin test, drug specific IgE test, basophil activation test, lymphocyte transformation test, et al) also provide evidences to identify the culprit drug.
