The relationship between inflammatory factors and depression and its mechanism exploration
10.3760/cma.j.cn112150-20210111-00026
- VernacularTitle:炎症因子与抑郁症的关联及其可能机制
- Author:
Yang HE
1
;
Shanshan CHEN
;
Puyu SU
Author Information
1. 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系 出生人口健康教育部重点实验室 人口健康与优生安徽省重点实验室，合肥 230032
- Keywords:
Depressive disorder;
Inflammatory;
Mechanism
- From:
Chinese Journal of Preventive Medicine
2021;55(4):539-544
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a common and recurrent mental disease, with complex etiology, which is mainly affected by genetic, metabolic and social factors. The specific pathogenesis is still unclear. In recent years, the hypothesis of inflammatory factors related to depression has attracted wide attention of researchers. A large number of clinical experimental studies have shown that depression is related to the increase of proinflammatory factors in central and peripheral blood. The inflammatory factors in peripheral blood can spread in the brain through the way of specific transporters across the blood-brain barrier, and activate or participate in the brain inflammatory response, and ultimately affect the neuronal activity and neurotransmitter release in the emotional regulation area of the brain, which in turn leads to depressive symptoms. This paper summarizes the relationship between inflammatory factors and depression and its possible mechanism, which provides reference for further prevention and control, clinical treatment and scientific research of depression.
