Research progress on antibody-dependent enhancement in infectious diseases

VernacularTitle:抗体依赖的增强作用在传染性疾病中的研究新进展
Author: Xiaoli LOU ¹ ; Deyong GAO ; Yanqiang HOU
Author Information

1. 上海交通大学医学院附属松江医院中心实验室，上海　201600
Keywords: Severe acute respiratory syndrome coronavirus 2; Antibody-dependent Enhancement; Severe acute respiratory syndrome coronavirus; Middle East respiratory s
From: Chinese Journal of Preventive Medicine 2021;55(2):171-176
CountryChina
Language:Chinese
Abstract: Antibody-dependent enhancement (ADE) refers to the process in which some virus-specific antibodies (generally non-neutralizing antibodies) bind to the virus and bind to some cells expressing FcR on the surface through their Fc segment, thereby mediating the endocytosis and replication of the virus and enhancing the infection of the virus. This review summarized experience of ADE in respiratory syncytial virus, dengue virus, influenza virus infection and explored the possible mechanism of COVID-19 high incidence and severity of the disease, which implied challenges in the process of vaccine development and provided some insights for COVID-19 pathogenesis.