Research progress on the regulation mechanism of Pseudomonas aeruginosa biofilm
10.3760/cma.j.cn112150-20200714-01002
- VernacularTitle:铜绿假单胞菌生物被膜调控机制的研究进展
- Author:
Zhijing ZHAO
1
;
Xinwei LIU
;
Xiaoqian ZHANG
;
Mengyu GUO
;
Yue HU
;
Dongmei LIU
;
Yongwei LI
Author Information
1. 河南中医药大学第二临床医学院检验中心，郑州市病原微生物与细菌耐药监测重点实验室, 郑州 450000
- Keywords:
Pseudomonas aeruginosa;
Biofilm;
Regulation mechanism
- From:
Chinese Journal of Preventive Medicine
2020;54(12):1469-1472
- CountryChina
- Language:Chinese
-
Abstract:
Pseudomonas aeruginosa is one of the common multidrug-resistant bacteria in the clinic. Because it can produce a "protective" biofilm, it can affect the penetration and killing efficacy of antibacterial drugs, leading to the formation of a persistent and persistent chronic infection in the host. Biofilms make Pseudomonas aeruginosa resistant to antibacterials and evasive to the host′s immune system. Therefore, traditional conventional antibacterials are difficult to achieve effective bactericidal treatment. Understanding the process of P. aeruginosa biofilm formation and the regulatory mechanisms that affect biofilms can provide ideas and methods for our future research on new antibacterial drugs.
