Total cholesterol and the risk of primary liver cancer in Chinese males: a prospective cohort study
10.3760/cma.j.cn112150-20190809-00646
- VernacularTitle:总胆固醇与男性原发性肝癌发病关系的前瞻性队列研究
- Author:
Yan WEN
1
;
Gang WANG
;
Hongda CHEN
;
Xin LI
;
Zhangyan LYU
;
Xiaoshuang FENG
;
Luopei WEI
;
Yuheng CHEN
;
Shuohua CHEN
;
Jiansong REN
;
Jufang SHI
;
Hong CUI
;
Shouling WU
;
Min DAI
;
Ni LI
Author Information
1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院早诊早治办公室，北京 100021
- Keywords:
Primary liver cancer;
Total cholesterol;
Male;
Cohort studies
- From:
Chinese Journal of Preventive Medicine
2020;54(7):753-759
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between total cholesterol (TC) and primary liver cancer in Chinese males.Methods:Since May 2006, all the male workers, including the employees and the retirees in Kailuan Group were recruited in the Kailuan male dynamic cohort study. Information about demographics, medical history and TC levels was collected at the baseline interview, as well as information on newly-diagnosed primary liver cancer cases during the follow-up period. A total of 110 612 males were recruited in the cohort by 31 December 2015. TC levels were divided into four categories by quartile (<4.27, 4.27-4.90, 4.90-5.56 and ≥5.56 mmol/L), with the first quartile group serving as the referent category. Cox proportional hazards regression model was used to evaluate the association between TC levels and primary liver cancer risk.Results:By December 31, 2015, a follow-up of 861 711.45 person-years was made with a median follow-up period of 8.83 years. During the follow-up, 355 primary liver cancer cases were identified. Compared with the first quartile, the HR of incident primary liver cancer among participants with the second, third and highest quartile TC levels were 0.76 (95% CI: 0.58-1.01), 0.59 (95% CI: 0.43-0.79), and 0.36 (95% CI: 0.25-0.52), respectively after adjusting for age, educational level, income level, smoking status, drinking status, body mass index, and HBsAg status ( P for trend<0.001). Subgroup analyses found that the association between TC levels and primary liver cancer was robust (all P for trend<0.05). The results didn’t change significantly after exclusion of newly-diagnosed cases within the first 2 years, males with history of cirrhosis or subjects who took antihyperlipidemic drugs, participants with higher TC levels had a lower risk of primary liver cancer (all P for trend<0.05) and HR(95% CI) of incident primary liver cancer among participants with the highest quartile TC levels were 0.41 (0.28-0.61), 0.36 (0.25-0.53) and 0.38 (0.26-0.54), respectively. Conslusion:In this large prospective study, we found that baseline TC levels were inversely associated with primary liver cancer risk, and low TC level might increase the risk of primary liver cancer.
