Effects of air pollution exposure on olfaction of rats in Beijing
10.3760/cma.j.cn112150-20200508-00699
- VernacularTitle:北京大气污染物暴露对大鼠嗅觉的影响
- Author:
Tenglong YAN
1
;
Jiao XIA
;
Jiayu XU
;
Pai ZHENG
;
Shupei ZHOU
;
Tian CHEN
;
Guang JIA
Author Information
1. 北京大学公共卫生学院劳动卫生与环境卫生学系 100191
- Keywords:
Air pollution;
Particle matter;
Ozone;
Olfactory perception
- From:
Chinese Journal of Preventive Medicine
2020;54(7):774-778
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of exposure of fine particle matter (PM 2.5) and ozone (O 3) in Beijing as the main pollutants on olfaction of SD rats. Methods:In October 16, 2018, twenty 8-week-old SD rats were randomly divided into two groups, 10 rats in the exposure group and 10 rats in the control group. They were fed in air pollutant exposure system and clean experimental environment respectively, and the concentrations of PM 2.5 and O 3 in each system were measured. The degree of olfaction damage of SD rats at different feeding time was assessed by using the buried food test (BFT). The difference of BFT time between the two groups was analyzed by performing the repeated measures analysis of variance. Results:The results showed that the concentrations of PM 2.5 and O 3 in the exposure group were (22.65±11.47) μg/m 3 and (12.36±5.87) μg/m 3, respectively, while those in the control group were both 0 μg/m 3. The repeated measures analysis of variance showed that the time of BFT in the exposure group was longer than that in the control group ( F=6.49, P=0.031). With the increase of feeding time, the time of BFT was prolonged ( F=61.69, P<0.001). Conclusion:Exposure to PM 2.5 and O 3in the atmosphere might lead to olfaction damage in rats.
