A birth cohort study of the association between prenatal serum bisphenol A concentration and infant neurobehavior development
10.3760/cma.j.cn112150-20190902-00696
- VernacularTitle:母亲孕期双酚A暴露与婴幼儿神经行为发育关联的出生队列研究
- Author:
Lianjie DOU
1
;
Qiufeng ZHANG
;
Huihui BAO
;
Wanke WU
;
Jie SHENG
;
Shuangqin YAN
;
Yuanyuan XU
;
Chunli GU
;
Kun HUANG
;
Hui CAO
;
Puyu SU
;
Fangbiao TAO
;
Jiahu HAO
Author Information
1. 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系 出生人口健康教育部重点实验室，合肥 230032
- Keywords:
Peripartum period;
Child, preschool;
Neurobehavioral manifestations;
Bisphenol A
- From:
Chinese Journal of Preventive Medicine
2020;54(6):644-650
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between maternal bisphenol A (BPA) exposure during pregnancy and neurobehavioral development in infant.Methods:Participants were from the Ma’anshan Birth Cohort, which was established from October 2008 to October 2010 based on four municipal medical and health institutions in Ma'anshan. High-performance liquid chromatography-tandem mass spectrometry was applied for the determination of serum BPA concentration in 1 783 pregnant women sampled at their first filing, and during 2.97 to 28.1 months age of the infants. Neurobehavioral development were assessed by 0-6-year-old pediatric examination table of neuropsychological development. Generalized linear model was used to analyze the association between serum BPA levels during pregnancy and infants’ neurobehavioral development.Results:A total of 931 mother-child pairs had complete data on serum BPA detection during pregnancy and assessment of infants’ neurobehavioral development status. The age of pregnant women at their first filing was (26.67±3.45) years old, and the M ( P25, P75) of serum BPA concentration (ng/ml) was 0.23 (0.11, 0.52), with a detection rate of 84.1% (783/931). The age of infants was (13.18±5.46) months, and 53.5% (498) were boys. The developmental quotient scores of large motor, fine motor, adaptive ability, language ability and social behaviors of infants were (97.88±16.32), (97.16±15.35), (99.64±15.47), (95.3±16.04) and (98.95±14.76) points, respectively. Generalized linear model showed that after adjusting for factors such as delivery mode, feeding mode, family per capita monthly income, preterm delivery, gender, maternal age, residence, pre-pregnancy body mass index and residence time, serum BPA level in pregnancy was negatively associated with infant’s development of social behavior [β (95% CI):-2.42 (-4.71, -0.12)]. The post-stratification analysis by infant age revealed that the serum BPA level in pregnancy was only negatively associated with the development of language and social behavior developmental quotient scores in infants between the ages of 12 and 18 months, with β (95% CI) about -6.66 (-13.06, -0.25) and -7.401 (-12.97, -1.83), respectively. Conclusion:BPA exposure during pregnancy affects language and social behavior development in infants, and the detection window is between 12 and 18 months old of the infant.
