Status of non?steroidal anti?inflammatory drugs use in areas with a high incidence of upper gastrointestinal cancer in China: a multi?center cross?sectional survey
10.3760/cma.j.issn.0253?9624.2019.11.005
- VernacularTitle:中国上消化道癌高发区非甾体类抗炎药使用情况研究
- Author:
Shuanghua XIE
1
;
Ru CHEN
;
Deli ZHAO
;
Yuqin LIU
;
Changqing HAO
;
Yongzhen ZHANG
;
Guohui SONG
;
Zhaolai HUA
;
Jialin WANG
;
Shuzheng LIU
;
Liwei10 ZHANG
;
Dantong SHAO
;
Yu QIN
;
Minjuan LI
;
Jiachen ZHOU
;
Rongshou ZHENG
;
Guiqi WANG
;
Wenqiang WEI
Author Information
1. 国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院肿瘤登记办公室
- Keywords:
Anti?inflammatory agents,non?steroidal;
Cross?sectional study;
Usage
- From:
Chinese Journal of Preventive Medicine
2019;53(11):1098-1103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To describe the status of non?steroidal anti?inflammatory drugs (NSAIDs) use in areas with a high incidence of upper gastrointestinal cancer in China. Methods This study was based on the National Key Research and Development Program of "National Precision Medicine Cohort of Esophageal Cancer" and "Study on Identification and Prevention of High?risk Populations of Gastrointestinal Malignancies (Esophageal cancer, Gastric cancer and Colorectal cancer)". From January 2017 to August 2018, 212 villages or communities with a high incidence of esophageal cancer or gastric cancer were selected from 12 regions in 6 provinces. A total of 35 910 residents aged between 40 and 69 years old who met the inclusion criteria and signed the informed consent were investigated and enrolled in this study. The use of NSAIDs, demographic characteristics, health?related habits, height, weight, and blood pressure were collected by the questionnaire and physical examination. The status of main NSAIDs (aspirin, acetaminophen and ibuprofen) use with the difference varying in genders, age groups and regions were analyzed by using χ2 test and Cochran?Armitage trend analysis method. Results Of 35 910 subjects, the mean age was (54.6 ± 7.1) years old and males accounted for 43.42% (15 591). The overall prevalence of NSAIDs intake was 4.56% (1 638), but it significantly varied in different provinces (P<0.001). The overall prevalence of NSAIDs intake was 4.87% (1 750) in females, which was significantly higher than that in males 4.24% (1 524) (P<0.001). The prevalence of NSAIDs intake increased with age (P for trend<0.001). As the frequency of NSAIDs intake increased, the incidence of gastrointestinal symptoms, gastrointestinal ulcers and black stools increased (P for trend<0.05 for all). Conclusion The use of NSAIDs is prevalent in some areas with a high incidence of upper gastrointestinal cancer in China. The increased use of NSAIDs may lead to more adverse effects related to the gastrointestinal tract.
