Prenatal lead exposure related to cord blood brain derived neurotrophic factor (BDNF) levels and impaired neonatal neurobehavioral development
10.3760/cma.j.issn.0253-9624.2016.06.008
- VernacularTitle:神经行为与不同铅暴露水平新生儿脐血中脑源性神经生长因子含量的相关性研究
- Author:
Lihua REN
1
;
Xiuying MU
;
Hongyan CHEN
;
Hongli YANG
;
Wei QI
Author Information
1. 山西省人民医院预防保健处
- Keywords:
Lead poisoning,nervous system;
Brain-derived neurotrophic factor;
Neonatal behavioral neurological assessment;
Cord blood
- From:
Chinese Journal of Preventive Medicine
2016;50(6):514-518
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between umbilical cord blood brain-derived neurotrophic factor (BDNF) and neonatal neurobehavioral development in lead exposure infants. Methods All infants and their mother were randomly selected during 2011 to 2012, subjects were selected according to the umbilical cord blood lead concentrations, which contcentration of lead was higher than 0.48μmol/L were taken into high lead exposure group, about 60 subjects included. Comparing to the high lead exposure group, according to gender, weight, pregnant week, length and head circumferenece, the level of cord blood lead concentration under 0.48μmol/L were taken into control group, 60 cases included. Lead content was determined by graphite furnace atomic absorption spectrometry. Neonatal behavioral neurological assessment (NBNA) was used to determine the development of neonatal neuronal behavior. The content of BDNF was detected by ELISA. Comparing the BDNF and the NBNA score between two groups, and linear correlation was given on analysis the correlation between lead concentration in cord blood and BDNF, BDNF and the NBNA score. Results Lead content in high exposure group was(0.613± 0.139)μmol/L,and higher than(0.336±0.142)μmol/L in low exposure group(t=3.21,P<0.001). NBNA summary score (36.35±1.86), active muscle tension score (6.90±0.27) and general assessment score (5.93± 0.32) in high exposure group were lower than those(38.13 ± 0.96, 7.79 ± 0.35, 6.00 ± 0.00)in low exposure group(t values were 8.21, 10.23, 2.32,respectively,P values were <0.001,<0.001 and 0.037). BDNF content in high exposure group which was(3.538±1.203)ng/ml was higher than low exposure group(2.464± 0.918)ng/ml (t=7.60,P<0.001). The correlation analysis found that the cord blood BDNF content was negatively correlated with NBNA summary score, passive muscle tension and active muscle tone score(r was-0. 27,-0.29,-0.30, respectively ,P values were <0.001, respectively). Conclusion Prenatal lead exposure results poor neonatal neurobehavioral development and cord blood BDNF was negatively correlated with neonatal neurodevelopment, may serve as a useful biomarker.
