Genetic Correlation of Community-Associated Methicillin-Resistant Staphylococcus aureus Strains from Carriers and from Patients with Clinical Infection in One Region of Korea.
10.3346/jkms.2010.25.2.197
- Author:
In Gyu BAE
1
;
Jae Seok KIM
;
Sunjoo KIM
;
Sang Taek HEO
;
Chulhun CHANG
;
Eun Yup LEE
Author Information
1. Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea. ttezebae@gmail.com
- Publication Type:Original Article
- Keywords:
Methicillin-Resistant Staphylococcus aureus;
Community-Acquired Infections;
Genotype;
Carrier State
- MeSH:
Community-Acquired Infections/microbiology;
Genotype;
Humans;
Methicillin-Resistant Staphylococcus aureus/*genetics/isolation & purification;
Microbial Sensitivity Tests;
Prospective Studies;
Republic of Korea;
Staphylococcal Infections/*microbiology
- From:Journal of Korean Medical Science
2010;25(2):197-202
- CountryRepublic of Korea
- Language:English
-
Abstract:
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is an increasingly common worldwide and colonizing S. aureus strains may serve as the causative pathogen for overt clinical infections. This study was performed to determine whether the pathogenic CA-MRSA isolate in clinical infections was genetically related to the MRSA isolates in community carriers. We prospectively collected a total of 42 CA-MRSA isolates (23 clinical infection isolates and 19 colonization isolates) in a local region of Korea. Antimicrobial susceptibility tests, staphylococcal toxin assays, SCCmec typing, multilocus sequence typing (MLST), and spa (staphylococcal protein A) typing were performed with all isolates. Thirty-four (81%) of 42 CA-MRSA isolates belonged to sequence type (ST) 72 in the MLST analysis. The distribution of STs did not differ significantly between colonization and clinical infection isolates (89.5% [17/19] vs. 73.9% [17/23], P=0.26). Among the ST72-MRSA isolates, spa type t664 (18, 52.9%) and t324 (8, 23.5%) were common in both groups. This study demonstrates that the community-associated MRSA strains from patients with clinical infections are closely related to the strains found in carriers from one local community.
