The advance of model of action in low-dose chronic benzene exposure induced hematotoxicity

VernacularTitle:慢性低剂量苯暴露血液毒性毒作用模式研究进展
Author: Chen GAO ¹ ; Zhengbao ZHANG ; Liping CHEN ; Wen CHEN
Author Information

1. 中山大学公共卫生学院
Keywords: Benzene; Toxic action; Key events; Hematotoxicity
From: Chinese Journal of Preventive Medicine 2015;(9):840-843
CountryChina
Language:Chinese
Abstract: Benzene is classified as Group 1 carcinogen by IARC. It has been found that benzene induces hematotoxicity even in low dose exposure. The identification of key events during benzene induced hematotoxicty leads to adjustment of occupational exposure limits of benzene. In this review, we focus on the exposure, metabolism, target organs, key epigenetic changes, toxicty effects and end points of low-dose chronic benzene exposure induced hematotoxicity and finally discuss the perspectives on the future study of this area.