The effects of exposure to the famine during early life with elevated resting heart rate in the adult
10.3760/cma.j.issn.0253-9624.2015.07.005
- VernacularTitle:生命早期饥荒暴露对成年后静息心率增快的影响
- Author:
Yuqing LI
1
;
Liyuan ZHU
;
Jierui WANG
;
Shuohua CHEN
;
Wei WEN
;
Hongfeng HAN
;
Chunpeng JI
;
Liufu CUI
;
Shouling WU
Author Information
1. 河北联合大学附属开滦总医院心内科
- Keywords:
Heart rate;
Physical examination;
Logistic models;
Early life;
Famine
- From:
Chinese Journal of Preventive Medicine
2015;(7):600-604
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between exposure to the famine during early life and elevated resting heart rate(RHR)in adulthood. Method From June 2006 to October 2007, the employees of kailuan group who took part in the health examination were selected. Of those, 18 619 cases who was born during October 1 ,1956 to September 30,1964 in Hebei province were finally included in the analysis based on the inclusion and exclusion criteria. All the subjects were received questionnaire survey, smoking and drinking, physical examination, Lab examination and the measurement of RHR. The subjects of famine exposure group(3 190 cases) were born from October 1 ,1959 to September 30, 1961,semi?exposure group( 3 851 cases) were born from October 1,1958 to September 30, 1959 and from October 1, 1961 to September 30, 1962 ,control group(11 578 cases) were born from October 1, 1956 to September 30, 1958 and from October 1, 1962 to September 30, 1964. The RHR and the detection rate of elevated RHR were compared among the three groups. The Multivariate logistic regression model was used to analyze the association between of exposure to famine during early life and elevated RHR in adulthood. Results The RHR level was higher in famine exposure group and semi?exposed group than control group, which were (74.34 ± 9.71),(74.41 ± 9.48)and(73.90 ± 9.45)beat per minute(bpm)(P values were 0.003 and 0.020, respectively).In all of the subjects. The results of multivariate logistic regression showed that exposure of famine during early life increased the risk of elevated RHR in adulthood after adjustment for age,gender and other confounders (OR=1.10, 95%CI:1.01-1.21). In men, exposure of famine during early life also increased the risk of elevated RHR in adulthood(OR=1.15, 95%CI:1.04-1.28);In women, there was no association between the famine exposure and elevated RHR (OR=0.92,95%CI:0.74-1.14). Conclusion Exposure of famine during early life increases the risk of elevated RHR in adulthood. This negative effect existed mainly in the male.
