Accuracy of immunochemical faecal occult blood test for colorectal cancer:meta-analysis
10.3760/cma.j.issn.0253-9624.2015.05.004
- VernacularTitle:免疫法粪便隐血试验检测大肠癌准确度的Meta分析
- Author:
Yansong JIANG
1
;
Guoxiang LIU
;
Huiyao HUANG
;
Weidong HUANG
;
Xin ZHANG
;
Wenqi FU
;
Min DAI
;
Jufang SHI
Author Information
1. 150086哈尔滨医科大学卫生管理学院
- Keywords:
Colorectal neoplasms;
Sensitivity and specificity Screening;
Feacal occult blood test;
Meta-analysis
- From:
Chinese Journal of Preventive Medicine
2015;(5):392-398
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the accuracy of immunological fecal occult blood test (iFOBT) for detection of colorectal cancer (CRC). Methods A total of 1 197 studies published before June 2014 were selected from PubMed and Embase and 17 of which were finally included in this meta-analysis. A bivariate mixed-effects models was used for overall value merging and heterogeneity testing. In addition to the overall sensitivity and specificity, the analyses were also performed among certain subgroups, including a“colonoscopy group”(all were referred for colonoscopy diagnosis regardless screening results) and a"follow-up group" (only the screening positive were referred and all were then followed up), a qualitative group and a quantitative group (classified by the way of iFOBT result reading). Results A total of 161 502 subjects aged from 48 to 63 years were included in the analysis. IFOBT had an overall integrated sensitivity of 0.85 (95%CI:0.79-0.89)(heterogeneity test:Q=59.67,P<0.001)and an overall integrated specificity of 0.93 (95%CI:0.92-0.94)(heterogeneity test:Q=1 722.53,P<0.001)for detection of CRC. In the subgroup analysis, it was found that in the"colonoscopy group"and in the"follow-up group", the sensitivity were 0.81 (95%CI: 0.73-0.87) and 0.88 (95%CI: 0.81-0.92), respectively; the specificity were 0.92 (95%CI: 0.89-0.93) and 0.95 (95%CI: 0.94-0.96), respectively. It was also found that in the qualitative group and the quantitative group, the sensitivity were 0.84 (95%CI:0.76-0.90) and 0.86 (95%CI:0.78-0.92), respectively;the specificity were 0.94 (95%CI: 0.91-0.96) and 0.93 (95%CI: 0.91-0.94), respectively. Conclusion IFOBT had high overall sensitivity and specificity for detecting colorectal cancer.
