Antibody persistence following booster vaccination with three doses of hepatitis B vaccines among low-response adults in Zhangqiu county of Shandong province:24-month of follow-up from 2009
10.3760/cma.j.issn.0253-9624.2014.12.005
- VernacularTitle:成年人乙型肝炎疫苗低应答者加强免疫后24个月免疫持久性研究
- Author:
Bingyu YAN
1
;
Jingjing LYU
;
Jiaye LIU
;
Yi FENG
;
Aiqiang XU
;
Shiyu CHEN
;
Libo ZHOU
;
Xiaofeng LIANG
;
Fuqiang CUI
;
Fuzhen WANG
;
Li ZHANG
Author Information
1. 山东省疾病预防控制中心免疫预防管理所 山东省传染病预防控制重点实验室
- Keywords:
Adult;
Hepatitis B vaccine;
Immunization,secondary;
Low-respond;
Immune persistence
- From:
Chinese Journal of Preventive Medicine
2014;(12):1043-1047
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the 24-month efficacy after booster vaccination with 3 doses of hepatitis B vaccine among low-response adults in Zhangqiu county of Shandong province.Methods A total of 24 237 adults aged 18-49 years old, never received HepB vaccination,without HBV infection history,and had been living at 3 towns of Zhangqiu county in Shandong province for more than half a year in september, 2009,were collected blood samples of 3-5 ml.A total of 11 590 adults who were negative for hepatitis B virus (HBV)surface antigen(HBsAg),antibody to HBsAg(Anti-HBs)and antibody to HBV core antigen(Anti-HBc),were divided into four groups randomly and were vaccinated following the schedule of 0-1-6 with 20 μg hepatitis B vaccine made by recombinant deoxyribonucleic acid techniques in Saccharomyces cerevisiae ( HepB-SC) , 20μg hepatitis B vaccine made by Chinese hamster ovary cell ( HepB-CHO) , 10μg HepB-SC and 10 μg hepatitis B vaccine made by recombinant deoxyribonucleic acid techniques in Hansenula Polymorpha ( HepB-HP ) , respectively. The adults who were low-response to the primary hepatitis B vaccination ( 10 mU/ml≤anti-HBs <100 mU/ml ) were divided into four groups by cluster random sampling.These groups were revaccinated with 3-dose of above-mentioned four kinds of HepB respectively.Blood samples were drawn from 1month( T1 ) and 24 month( T24 ) after the 3 dose revaccination, respectively.Anti-HBs and anti-HBc was detected by Chemiluminescence Microparticle Imunoassay( CMIA) . Results Out of the 8 592 adults who have accepted the primary vaccination of hepatitis B and been collected the blood samples,1 306 subjects showed low-response.A total of 718 low-response subjects were collected blood samples after T1 and T24 following 3 doses of booster vaccination.The proportion of the four groups was 32.3% ( 232/718 ) , 25.8% ( 185/718 ) , 19.3% ( 139/718 ) , 22.6% ( 162/718 ) , respectively.The average proportion of anti-HBs≥100 mIU/ml were decreased from 77.58% after T1 to 35.63%after T24(χ2 =256.87,P<0.01).The proportion of anti-HBs≥100 mIU/ml in T24 were 38.8%(90/177),39.5%(73/185),25.2%(35/139) and 35.8%(58/162) in four groups,respectively.The proportion of anti-HBs >100 mIU/ml in T24 was significantly different among groups (χ2 =8.81, P =0.032).The average geometric mean concentration(GMC) was significantly reduced from 443.53 mIU/ml after T1 to 48.98 mIU/ml after T24 (F =439.41,P<0.01).The GMC was 60.26(45.71-77.62),1.29 (38.90-69.18),35.48(25.70-48.98) and 46.77(33.88-6.07) mIU/ml in four groups,respectively(F=1.97,P=0.117).Compared with vaccinated 20 μg HepB-SC, the proportion of anti-HBs≥100 mIU/ml and GMC was 0.56(0.35-0.91) and -0.20(-0.39--0.02)times.The positive of HBsAg was not found and the positive rate of anti-HBc was 2.6% ( 18/692 ) in T24 .Conclusion Protective antibody following booster vaccination with three doses of hepatitis B vaccines among low-response adults after 2 years fade faster.Antibody level of anti-HBs in T24 was corrected with the booster vaccine type and age.20μgHepB-SC seemed better than 10 μg HepB-SC.
