Analysis of antibodies of poliviruses in persistent populations in Beijing,2012
10.3760/cma.j.issn.0253-9624.2014.09.004
- VernacularTitle:北京市2012年常住人口脊髓灰质炎病毒抗体水平分析
- Author:
Jiazi ZHANG-ZHU
1
;
Herun ZHANG
;
Renqing LI
;
Yang ZENG
;
Xiaomei LI
;
Jingbin PAN
;
Hao SUN
;
Zhongzhan WANG
;
Fangru GUO
;
Yihua ZHANG
;
Fengshuang WANG
;
Tao WU
;
Xinghui PENG
;
Li LU
;
Xinghuo PANG
Author Information
1. 100013,北京市疾病预防控制中心免疫预防所
- Keywords:
Poliovirus;
Antibody,neutralized;
Immunity;
Positive rate;
Geometric mean titers
- From:
Chinese Journal of Preventive Medicine
2014;(9):762-765
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the polio immunity level of persistent population in Beijing , 2012.Methods A total of 1 676 subjects residing more than 6 months in Beijing were selected by stratified random cluster sampling design in 2012.Demographic characteristics , history of oral poliovirus vaccine ( OPV) immunization were investigated by questionnaire.All 5 ml blood sample were collected for testing of polio neutralizing antibody using the method of microcell neutralization.The positive rate and the geometric mean titer ( GMT ) of polio neutralizing antibody type Ⅰ,Ⅱ and Ⅲ were analyzed in different groups.Results The positive rate of type Ⅰ,Ⅱ and Ⅲ were 98.2%( 1 645/1 676 ) , 98.1%( 1 644/1 676),97.6%(1 635/1 676);The GMT were 1∶130.2,1∶113.4 and 1∶79.7.Three types of positive rates in<15 years group(99.7%(664/666),99.8%(665/666),99.5%(663/666)) were higher than those of≥15 years group (97.1%(981/1 010),96.9%(979/1 010),96.2%(972/1 010)),the differences were significant(all the values of P<0.01); The GMT in<15 years group(1∶325.9,1∶250.5,1∶190.7)were higher than that of ≥15 years group (1∶71.1,1∶67.2,1∶44.8),the difference was significant (all the values of P<0.01).The positive rate(99.0%-100%) and GMT(1∶128.8-1∶300.7) in vaccination information confirmed population were higher.The highest positive rate (all were 100%) and GMT(1∶409.7-1∶636.7) were observed in children who vaccinated three times.Conclusion The polio antibody of healthy population was at a high level in Beijing in 2012; Especially the age groups of <15 years which were covered by vaccines.Immunization barrier had been formed firmly to interrupt the transmission of wild poliovirus and vaccine-derived poliovirus.
