The treatment strategies for the repair of intervertebral disc degeneration
10.3760/cma.j.cn112139-20240218-00072
- VernacularTitle:椎间盘退变修复相关治疗方法的研究现状
- Author:
Yao WANG
1
;
Xiaoyu CAI
;
Weibin SHENG
Author Information
1. 新疆医科大学第一附属医院脊柱外科，乌鲁木齐 830054
- Keywords:
Intervertebral disc;
Regeneration;
Intervertebral disc degeneration;
Molecular therapy;
Gene therapy;
Cell therapy;
Biomaterial therapy
- From:
Chinese Journal of Surgery
2024;62(9):887-892
- CountryChina
- Language:Chinese
-
Abstract:
The traditional treatment of intervertebral disc degeneration (IVDD) mainly focuses on symptomatic treatment, and cannot restore the physiological structure and function of the intervertebral disc. Therefore, more and more scholars begin to pay attention to the application of regenerative medicine and its derived therapeutic methods in IVDD. From the histological perspective, the early stage of IVDD shows the imbalance between synthesis and catabolism, but the cell number and tissue structure are relatively complete, and the intervention of exogenous molecules or gene therapy can achieve extracellular matrix (ECM) regeneration. With the progress of IVDD, the replenishment of healthy cells is the key to treatment. In the final stage, the cell number and tissue structure are disordered. Biological materials with certain mechanical strength and cell load can be used to supplement ECM and healthy cells to realize the repair and regeneration of IVDD. Molecular, cell and gene therapy, combined with the application of new biomaterials, the treatment of IVDD is more inclined to compensate for the shortcomings through a combination approach in the future, in order to achieve the purpose of repair and regeneration.
