Advances in warfarin′s anticoagulation therapy in Chinese population after mechanical valve replacement
10.3760/cma.j.cn112139-20231021-00184
- VernacularTitle:机械瓣膜置换术后中国人群华法林抗凝治疗的研究进展
- Author:
Junhang JIA
1
;
Cong CHEN
;
Kui ZHANG
;
Ran DONG
Author Information
1. 首都医科大学附属北京安贞医院心脏外科，北京 100029
- Keywords:
Heart valve diseases;
Heart valve prosthesis implantation;
Warfarin;
Pharmacogenetics;
Mechanical valve replacement
- From:
Chinese Journal of Surgery
2024;62(5):461-466
- CountryChina
- Language:Chinese
-
Abstract:
Warfarin is an irreplaceable oral anticoagulant for patients with mechanical heart valves, the stable pharmacogenetic-based warfarin dose prediction algorithms have improved the effectiveness and safety of warfarin anticoagulation therapy. Genetic factors are the main factors affecting the stable dose of warfarin. Single nucleotide polymorphisms such as VKORC1 and CYP2C9 affect the anticoagulation effect of warfarin through pharmacodynamic or pharmacokinetic pathways. Age, body surface area, combined use of drugs, and other nongenetic factors also affect the stable dose of warfarin. Previously published algorithms for warfarin dose prediction included mainly the white race, and most algorithms were constructed using traditional multiple linear regression. However, domestic studies have used machine learning methods to construct warfarin dose prediction algorithms based on the Chinese Han post-mechanical valve replacement population and have achieved better prediction efficiency. This article reviews the advances of warfarin anticoagulation influencing factors and the clinical application of stable dose prediction algorithms.
