Advancements and controversies in conversion therapy for biliary tract malignant tumors with insufficient future liver remnant
10.3760/cma.j.cn112139-20231218-00283
- VernacularTitle:余肝体积不足胆道恶性肿瘤转化治疗的进展与争议
- Author:
Zhao WANG
1
;
Defei HONG
Author Information
1. 郑州大学第一附属医院肝胆外科，郑州 450052
- Keywords:
Biliary tract neoplasms;
Surgical procedures, operative;
Future liver remnant;
Relieve jaundice treatment;
Conversion therapy;
Treatment strategy
- From:
Chinese Journal of Surgery
2024;62(4):284-289
- CountryChina
- Language:Chinese
-
Abstract:
Due to the unique location and aggressive tumor biology,hilar cholangiocarcinoma,intrahepatic cholangiocarcinoma,and gallbladder cancer often present with obstructive jaundice and require extensive liver resection,also exhibit high rates of recurrence and metastasis after radical excision. Therefore,surgeons should make treatment decisions based on the biliary anatomy of patients and the biological characteristics of tumors as it significantly affects patient′s prognosis. Treatment strategy should be made to ensure the successful implementation of radical resection for biliary tract malignant tumors while maximizing the survival benefits of patients. Firstly,conversion of liver function by relieving jaundice technology and conversion of tumor biological characteristics through systematic therapy,followed by the conversion of future liver remnant. Currently,there are still controversies surrounding indications,methods,standards of relieving jaundice,and treatment plans,cycles,evaluation of therapeutic effects for systematic conversion therapy,and the standards and techniques of conversion therapy for future liver remnant.This article discusses these issues through literature analysis and the author′s experience in the hope of resonating with colleagues.
