Advances in oncolytic virotherapy for glioma
10.3760/cma.j.cn112139-20230908-00100
- VernacularTitle:溶瘤病毒在脑胶质瘤治疗中的研究进展
- Author:
Guanglin ZHU
1
;
Shuai WU
;
Jinsong WU
Author Information
1. 复旦大学附属华山医院神经外科，上海 200040
- Keywords:
Glioma;
Oncolytic viruses;
Immunotherapy
- From:
Chinese Journal of Surgery
2024;62(1):76-81
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, there has been significant progress in the research of oncolytic viruses for the therapy of gliomas. The latest clinical trial results related to the modification, effectiveness, and safety of oncolytic viruses have brought hope for the development of glioblastoma treatments. Modified oncolytic viruses, particularly those based on the herpes simplex virus, have gained approval in Japan. Clinical trials involving recombinant poliovirus have shown better-than-expected survival outcomes with a strong safety profile. Notably, the first-time report of adenovirus in combination with immune checkpoint inhibitors for glioblastoma has demonstrated promising survival benefits and safety. However, challenges remain, including the selection of administration routes and the sustainability of treatment effects during oncolytic virus therapy. Therefore, further preclinical and clinical studies are required to improve the effectiveness and optimize treatment strategy for glioblastoma using oncolytic viruses.
