Correlation between C-reactive protein to albumin ratio and restenosis after femoral popliteal stenting in patients with lower extremity arteriosclerotic obliterans
10.3760/cma.j.cn112139-20230815-00047
- VernacularTitle:C反应蛋白与血清白蛋白的比值与下肢动脉硬化闭塞症患者股腘支架置入术后再狭窄的相关性研究
- Author:
Yimei WANG
1
;
Mengqiang ZHANG
;
Zhipeng CHEN
;
Run JI
;
Jing CAI
;
Tong QIAO
Author Information
1. 南京中医药大学鼓楼临床医学院，南京210008
- Keywords:
Arteriosclerosis obliterans;
Stents;
restenosis;
Inflammatory factor;
C-reactive protein;
Serum albumin
- From:
Chinese Journal of Surgery
2023;61(12):1058-1064
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the study of the correlation between C-reactive protein to albumin ratio (CAR) and restenosis after stenting in patients with lower extremity atherosclerotic occlusive disease(LEASO).Methods:The clinical data of 95 patients with LEASO admitted to the Department of Vascular Surgery of Nanjing Drum Tower Hospital from June 2020 to December 2022 were retrospectively analyzed. There were 67 males and 28 females,aged (73.1±9.4) years (range:51 to 92 years). The patients were classified into the restenosis group ( n=61) and the patency group ( n=34) according to the CT angiography results. Independent sample t test,Mann-Whitney U test and χ2 test were used to compare the data between two groups. Risk factors for restenosis after femoropopliteal artery stenting in patients with LEASO were analyzed using multivariate Cox regression. The relationship between preoperative CAR level and restenosis after stent placement was analyzed. Subject operating characteristic(ROC) curves of CAR were plotted to assess the predictive value of CAR for restenosis after stenting,and the results were expressed as area under the curve (AUC). Results:The aortoiliac calcification grade,number of stents,length of stents,C-reactive protein and CAR levels in restenosis group were higher than those in the patency group,and the serum albumin level was lower than that in the patency group(all P<0.05). And the results of multifactorial Cox regression analysis showed that higher pre-procedure CAR level and lower ABI value was an independent risk factor for in-stent restenosis. The AUC of the ROC curve for restenosis was 0.737(95% CI:0.617 to 0.856),the AUC of the ROC curve for 12-month restenosis was 0.709(95% CI:0.602 to 0.815), and the AUC of the ROC curve for 24-month restenosis was 0.702(95% CI:0.594 to 0.811). Conclusion:Higher pre-procedural CAR levels in patients with LEASO is risk factor for in-stent restenosis,and CAR has a predictive value for restenosis after lower extremity arterial stent dilatation and angioplasty.
