Advances in combination strategies with oncolytic virotherapy
10.3760/cma.j.cn112139-20230514-00201
- VernacularTitle:溶瘤病毒联用疗法应用新进展
- Author:
Zhenglong ZHAI
1
;
Yinan SHEN
;
Xueli BAI
;
Tingbo LIANG
Author Information
1. 浙江大学医学院附属第一医院肝胆胰外科，杭州 310000
- Keywords:
Oncolytic viruses;
Combined modality therapy;
Advanced tumor;
Combination strategies
- From:
Chinese Journal of Surgery
2023;61(10):923-928
- CountryChina
- Language:Chinese
-
Abstract:
Compared with conventional treatments, oncolytic virotherapy has the advantages of enhanced cytotoxicity, improved targeting, and minimal side effects. However, its efficacy is not as good as expected for the single drug treatment. The purpose of synergistic effect is one of the development directions of existing oncolytic virus therapy. In this paper, through a systematic review of the current preclinical and clinical trials progress of oncolytic virus combination therapy, the combined treatment strategies of oncolytic virus and immune checkpoint inhibitors, chemotherapy, targeted therapy,and cell therapy are reviewed to provide reference for further clinical application.
