The multi-dimensional molecular characteristics of the indolent pulmonary ground-glass nodules
10.3760/cma.j.cn112139-20220129-00045
- VernacularTitle:惰性肺部磨玻璃结节的多维度分子特点
- Author:
Yun LI
1
;
Sida CHENG
;
Zihan WEI
;
Haifeng SHEN
;
Wenxiang WANG
;
Fan YANG
;
Kezhong CHEN
Author Information
1. 北京大学人民医院胸外科，北京 100044
- Keywords:
Lung neoplasms;
Pathology;
Ground-glass nodules;
Indolent clinical course;
Molecular characteristics
- From:
Chinese Journal of Surgery
2022;60(6):528-534
- CountryChina
- Language:Chinese
-
Abstract:
With the dramatically increasing detection rate of ground-glass nodules (GGN), exact understanding and treatment strategy of them has become the hottest issue currently. More and more studies have begun to explore the underlying mechanisms of their indolent characteristics and favorable prognosis from the perspectives of molecular evolution and immune microenvironment. GGN has different dominating gene mutations at different evolutional stages. The pure GGN has a lower tumor mutation burden and genomic instability, while a gradually evolutionary feature of genomic mutation along with the pathological progression can be observed. GGN has less infiltration of immune cells, and they are under the pressure of immune surveillance with weakened immune escape. With the increase of solid components, an inhibitory immune microenvironment is gradually established and immune escape is gradually enhanced, leading to rapid tumor growth. Further exploration of the molecular characteristics of GGN will help to more precisely distinguish these highly heterogeneous lesions, which could be helpful to make personalized treatment plans.
