Molecular targeted therapy strategy and clinical research progress in pancreatic ductal adenocarcinoma
10.3760/cma.j.cn112139-20201118-00804
- VernacularTitle:胰腺导管腺癌分子靶向治疗策略及临床研究进展
- Author:
Meng YUAN
1
;
Abuduhaibaier SADULLA
;
Siqian REN
;
Chunhui YUAN
Author Information
1. 北京大学第三医院普通外科 100191
- Keywords:
Pancreatic neoplasms;
Gene mutation;
Signal pathway;
Molecular targeted therapy;
Tumor microenvironment
- From:
Chinese Journal of Surgery
2021;59(11):956-960
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of pancreatic ductal adenocarcinoma(PDAC) is increasing year by year among digestive system tumors.It has a high degree of malignancy and a poor prognosis.Its five-year survival rate is less than 8%.Traditional radiotherapy and chemotherapy are not sensitive to pancreatic cancer,so finding a new drug is the future hope for pancreatic cancer.In recent years,molecular targeted therapy has made obvious progress in diseases such as hematological malignancies,non-small cell lung cancer and melanoma,and a large number of targets have been tried in pancreatic cancer, for example, gene mutation targets, important signaling pathway targets, receptor targets, etc. The use of these targeted drugs alone or in combination has shown good results in preclinical models and some clinical trials, and some treatment have been standardized for patients with pancreatic cancer, while other options that have not yet been tested in large-scale clinical trials also offer a variety of potential possibilities for future targeted treatments for pancreatic cancer.
