Research progress of osteoarthritis model
10.3760/cma.j.cn112139-20210113-00026
- VernacularTitle:骨关节炎模型的研究进展
- Author:
Xiaolong YANG
1
;
Lizhi ZHANG
;
Xiaodong LIU
Author Information
1. 上海市杨浦区中心医院（同济大学附属杨浦医院）骨科 200090
- Keywords:
Osteoarthritis;
Disease models, animal;
In vivo model;
In vitro model;
Non-invasive model
- From:
Chinese Journal of Surgery
2021;59(9):792-795
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of osteoarthritis is still not completely clear,the current treatment can not effectively prevent the disease from progressing.In order to study osteoarthritis,researchers have developed various models,including in vitro models (two-dimension and three-dimension cell culture models and bioreactor culture models) and in vivo models (spontaneous,genetically modified,invasive and non-invasive models).These models are important tools for studying the mechanism of disease occurrence and development,which can simulate the whole process or a certain stage of pathological changes,as well as evaluating the effect of treatment.This paper reviews the osteoarthritis models and their characteristics in order to provide reference for osteoarthritis research.
