Patterns of recurrence after neoadjuvant chemoradiotherapy compared with surgery alone in esophageal cancer
10.3760/cma.j.cn112139-20210228-00101
- VernacularTitle:从复发方式看食管癌新辅助治疗的内在机制
- Author:
Yushang YANG
1
;
Longqi CHEN
Author Information
1. 四川大学华西医院胸外科，成都 610041
- Keywords:
Esophageal neoplasms;
Antineoplastic combined chemotherapy protocols;
Neoadjuvant therapy;
Recurrence;
Prognosis
- From:
Chinese Journal of Surgery
2021;59(8):651-654
- CountryChina
- Language:Chinese
-
Abstract:
Associated with improvement in survival, the neoadjuvant therapy had become the mainstay of therapy for patients with locally advanced esophageal cancer. Despite a significantly better survival, the recurrence risk after neoadjuvant therapy remains considerably high, with recurrence rate of>40%. Thus, it′s important to gain a thorough understanding of the recurrence patterns for developing effective tertiary prevention and follow-up strategies. The aim of this review was to compare the patterns of recurrence in patients with esophageal cancer who received preoperative therapy followed by surgery or surgery alone. It is found that the most frequent recurrence pattern was distant metastasis in esophageal cancer regardless receipt of neoadjuvant therapy or not, and the major effect of neoadjuvant therapy appears to be an improvement in local regional disease control without a reduction in systemic. This frustrating fact may explain the poor survival of esophageal cancer patients receiving neoadjuvant therapy.
